DE-WORMERS & EXTERNAL PARASITIDES

VERMIVET POLIVITAMINADO BOTTLE WITH 250 ML (2BOTTELS)

VERMIVET POLIVITAMINADO BOTTLE WITH 250 ML (2BOTTELS)


SKU: VERMI
In stock: 20 units

Price: $ 100.00 USD*
* United States Dollars

DESCRIPTION

Vermivet ® Polivitaminado is a multivitamin antiparasitic agent  with broad spectrum in injectable solution, its active ingredient, levamisole chemically belongs to the group of imidazothiazoles, it also contains the fat-soluble vitamins A , D, E  and the water-soluble B complex that animals require.

Vermivet ® Polivitaminado  is indicated for the treatment and control of parasitosis, caused by gastrointestinal and pulmonary nematodes, both in the adult phase and in the larval phase and for the treatment of deficiencies of vitamins A, D, E and B complex, in cattle, sheep, goats and pigs

Vermivet ® Polivitaminado  has a double effect, vitamin and worming with a single application

Vermivet ® Polivitaminado  is a hydromiscible formula that allows rapid absorption and availability from the application site, facilitates the injection of the product, does not cause necrosis or abscesses at the application site.

Vermivet ® Polivitaminado  contributes in the improvement of the productive and reproductive parameters in treated cattle and improves the physical appearance of livestock. Avoid excessive handling of animals, therefore, reduces stress because with a single application manages to deworm and vitamin. It can be used simultaneously with the pre-established program of vaccination, does not interfere with the immune response on the contrary stimulates the immune system.

Vermivet ® Polivitaminado  contributes to improve fertility, prevent dystocia, avoid metabolic disorders such as hypocalcemia and rickets

Vermivet ® Polivitaminado  contributes to the regeneration of mucous membranes damaged by infections, prevents muscular dystrophy in calves and states of night blindness.

 

FORMULA

Each 5 ml contains Levamisol  Hydrochloride ......... 600 mg Vitamin A ....................... 500 000 UIVitamin  D ..... ..................75 000 UIVitamin  E ....................... 50 UIVitamin B  1  . ................... 25 mgVitamin B  2  .................... 10 mgVitamin B  3  ... ................. 50 mgVitamin B  5 .................... 10 mgVitamin B  6  ..... ............... 25 mgVitamin B  12  .................. 800 mcgVehicle cbp .......... ... 5 ml

INDICATIONS

Antiparasitic multivitamin with broad spectrum in injectable solution, indicated for the treatment and control of parasitosis, caused by gastrointestinal and pulmonary nematodes, both in the adult phase and in the larval phase and for the treatment of deficiencies of vitamins A, D, E and complex B in cattle, sheep, goats and pigs.

PHARMACOKINETICS AND PHARMACODYNAMICS

ABSORPTION.-  The hydromiscible presentation of Vermivet Polivitaminado, allows the levamisole and vitamins of its formula to mix quickly with tissue fluids, achieving a good absorption and total bioavailability.

Levamisole is absorbed quickly and effectively once injected parenterally. The bioavailability of levamisole is three times higher than when administered orally, especially at the level of the respiratory tract. Levamisole injected subcutaneously reaches maximum plasma levels at 30 minutes and at three to four hours is not detected in plasma.

Vitamins A, D and E are conveniently absorbed parenterally (intramuscularly). They are easily absorbed in the small intestine and because they are fat soluble, this absorption is related to that of the fat carrying the vitamins. Thus, the bile necessary for the absorption of lipids, it is also for vitamins A, D and E.

The B-complex vitamins are easily and completely absorbed when administered subcutaneously or intramuscularly, but when administered orally, intestinal absorption (small intestine) is limited, losing a large part in stool, especially when doses are administered. high or if there is diarrhea.

Cyanocobalamin (vitamin B  12)  is absorbed in the small intestine, after spending several hours in the lining of the ileum.

DISTRIBUTION.-  Levamisole is distributed very well throughout the body. Vitamin A is esterified to form retinyl palmitate. The intestinal absorption is produced especially by the lymphatic route and then reaches the blood in an esterified form, then stored in the liver, 95% of the body's content in said vitamin exists in the liver, the rest in the kidney and in the gland adrenal. From the liver, the vitamin is released into the circulation in the form of retinol.

Vitamin D once absorbed passes into the blood and from here it is stored in the liver, lung, kidney and spleen mainly.

Vitamin E once absorbed enters the bloodstream through the lymphatic system, is distributed in all tissues.

The B-complex vitamins once absorbed, pass into the blood and are distributed in all organs, especially liver, kidney and heart, but there is little cellular storage. The cyanocobalamin once absorbed is conjugated with transcobalamin in the plasma and is transported by the bloodstream to the liver.

  1. Levamisole is metabolized in the liver (four recognized processes); The main process is the hydrolytic rupture of the thiazide ring.

The metabolism of vitamin D is summarized below, cholecalciferol is transformed into 25-hydroxycholecalciferol by oxidation and that substance is the main and probably active metabolite of vitamin D.

Vitamins A and E are metabolized in the liver however their metabolites have not been well identified.

In animal tissues Thiamin exists almost exclusively as pyrophosphate, in the liver and brain that can transform Thiamine into cocarboxylase.

Riboflavin is partially metabolized in the body, but the metabolites formed are not known.

Niacinamide at the level of all cells forms coenzymes I and II.

Pyridoxine and derivatives are transformed into 4-pyridoxic acid.

Cyanocobalamin is metabolized in the liver.

EXCRETION.-  The elimination half-life of levamisole in plasma is 4-6 hours in cattle. Levamisole is excreted through urine, feces, milk and bronchial mucus. Only 0.9% of the initial dose stays in the tissues 12-24 hours after administration.

Vitamin A, once degraded, passes into the bile, but reabsorbs again in the intestine. It passes well to breast milk.

Vitamin D is eliminated by the bile and by the milk and the quantity present in the milk secretion is related to the ingestion of said vitamin.

Vitamin E is eliminated mainly by bile, very small amounts are eliminated in the urine and milk.

The B-complex vitamins, including cyanocobalamin, are eliminated mainly in urine, sweat and milk.

MECHANISM OF ACTION.-  Levamisole hydrochloride has a paralyzing action on nematodes. The paralysis is due to a sustained muscle contraction because it acts as a lymph node stimulator, causes contractions and relaxations followed by neuromuscular paralysis in the parasite by inhibition of acetylcholinesterase, concomitant with inhibition of fumarate reductase.

The immunostimulant effect of levamisole is attributed to the fact that it regenerates the immune function mediated through the cells in peripheral T lymphocytes  and stimulates phagocytosis through monocytes.

Vitamins are organic compounds necessary to maintain health, promote normal growth and development of tissues; they mostly play the role of coenzymes in the metabolic processes of the animal organism. The deficiency of one or some of them can cause disorders such as blindness, increased susceptibility to infectious processes, abortions, rickets, reproductive failures and poor feed conversion.

The addition of vitamins A, D, E, in addition to those of the B complex, makes it possible to prevent and contribute to the treatment of deficit states in all the species in which Vermivet Polivitaminado is applied. Its ease of use, reasonable margin of safety and lack of teratogenic effect, allows its successful application in cattle, sheep, goats and swine.

DOSE

Cattle: 1 ml per 15 to 20 kg of live weight. Ovines and Caprines: 1 ml per 20 kg of live weight. Porcini: 1 ml per 30 kg of live weight. Maximum dose per application site: 15 ml.

ROUTE OF ADMINISTRATION

Deep intramuscular

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